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Original Article
Clinical Observation on Splenectomized Children.
Mi Ryung Um, Jae Won Song, Yong Yull Koh, Jeong Kee Seo, Hyo Seop Ahn, Chang Yee Hong, Kwi Won Park
Clin Exp Pediatr. 1987;30(5):511-517.   Published online May 31, 1987
A clinical study was performed on 26 cases of splenectomized children who had been seen at the Department of Pediatrics, Seoul National University Hospital, during the period of 7 years 7 months from January 1978 to July 1985. The results were as follows: 1) Primary diseases were hereditary spherocytosis (8 cases), Hodgkin disease for staging laparotomy (8 cases), ...
Case Report
Hodgkin’s Disease in Children
Soo Jong Hong, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(12):1352-1359.   Published online December 31, 1986
Twenty one cases of Hodgkin’s disease under 15 years of age who were admitted to Dept, of Ped. of Seoul National University Hospital from Jan. 1976 to Dec. 1985 were reviewed and analysed. One hundred and five cases of non-Hodgkin’s lymphoma were seen during the same period. 1) The ratio of non-Hodgkin’s lymphoma to Hodgkin's disease was 5:1. 2) The age ranged from 18/12 years...
Original Article
Herpes Zoster in Children.
Soon Ki Kim, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1986;29(12):1324-1333.   Published online December 31, 1986
Herpes zoster, an inflammatory human disease caused by varicella-zoster virus, is characterized by papulovesicular lesions along the distribution of a sensory nerve. Herpes zoster infection, known to be benign in normal children, is more frequent and severe in immunosuppressed patients and is associated primarily with increased morbidity rather than mortality. We analysed retrospectively the clinical manifestations of herpes zoster infections...
Experimental Diphtheritic Myocarditis with Special Reference to Ultrastructural Changes.
Hyo Seop Ahn
Clin Exp Pediatr. 1986;29(12):1295-1308.   Published online December 31, 1986
Myocardiopathy following diphtheria infection is one of the most serious and fatal complications, but its nature of the lesion remained in controversy, and even ultrastructural understanding on the direct effect of diphtheria toxin has not been clarified. The purpose of this experiment is to illustrate the full morphological spectrum of subclinical or EKG free diphtheritic myocardial injuries by administration of...
Case Report
A Case of Chronic Myelogenous Leukemia in a Child Treated in a Interferon.
Ill Soo Ha, Jon Lin Rhi, Se Jung Sohn, Dug Ha Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(11):1232-1238.   Published online November 30, 1986
A child with Ph^positive chronic myelogenous leukemia was treated with human leukocyte interferon (Hu IFN-alpha). Hematologic remission was obtained in 16 weeks of treatment, and white blood cell count was decreased in number from 115,000 to 9,600. Platelet：count, spleen size, LDH and bone marrow M/E ratio were decreased in parallel, but there was no significant change in serum vitamin B12...
Original Article
Gangliosides in Malignancy.
Hyo Seop Ahn
Clin Exp Pediatr. 1986;29(6):583-586.   Published online June 30, 1986
Case Report
Two Cases of Hemolytic Disease of Newborn due to Anti-E.
Se Won Park, Young Sun Kim, Jung Hwan Choi, Hyo Seop Ahn, Chong Ku Yun
Clin Exp Pediatr. 1986;29(2):203-208.   Published online February 28, 1986
Isoimmune hemolytic disease of the newborn is a disease which is caused by maternal sensitization to one of the fetal blood factors. This report presented two esses of isoimmune hemolytic disease due to anti-E in 2 male newborns who were admitted to Seoul University Hospital because of jaundice. Antibody screening and antibody identification tests were made which revealed anti-E antibody...
A Case of Niemann-Pick Disease with Sea-Blue histiocytes in the Bone Marrow.
Young Sun Kim, Soo Heum Lim, Jeong Kee Seo, Hyo Seop Ahn, Hyung Ro Moon
Clin Exp Pediatr. 1985;28(12):1238-1244.   Published online December 31, 1985
A case of Niemann-Pick disease in a 12 year and 6 month old Korean male was reported. The patient showed marked hepatosplenomegaly without neurologic symptoms. Fundoscopic examination revealed a cherry-red spot with white ring in the maculae. Numerous foamy histiocytes and sea-blue histiocytes were seen in the bone marrow. The liver biopsy specimen showed the diffuse ballooning of hepatocytes obliterating...
Three Cases of Congenital Hypoplastic Anemia.
Heui Jeong Kwon, Myung Hyun Lee, Jung Hwan Choi, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1985;28(8):829-835.   Published online August 31, 1985
Congenital hypoplastic anemia is a rare disease characterized by aplasia or severe hypoplasia of the erythron, with onset usually at birth or during early infancy. This report presented three cases of congenital hypoplastic anemia in 3 infants with pallor and irritability which were noticed since one to three months of age. Three cases were treatsd with prednisolone and the courses of...
Original Article
A clinical study on Myasthenia gravis in childhood.
Yong Seung Hwang, Hyo Seop Ahn, Sang Hyup Kim
Clin Exp Pediatr. 1985;28(2):154-159.   Published online February 28, 1985
Twenty-six cases of myasthenia gravis (MG) in childhood who were diagnosed and treated in the Department of Pediatrics, Seoul National University Hospital from January 1976 till October 1984 were reviewed clinically. Mean age of onset of MG was 5.4+3.6 years of age with the peak incidence at 2 years of age. Sexual difference was negligible as male to female ratio...
Clinical Review of Abdominal Masses in Infant and Children .
Dong Hyun Choo, Chong Young Pakr, Sang Pok Suk, Jeong Kee Seo, Hyo Seop Ahn, Kwang Wook Ko
Clin Exp Pediatr. 1984;27(12):1202-1212.   Published online December 31, 1984
One hundred and ninety four patients who were admitted with the chief complaint of abdominal mass were reviewed. The result were as follows; 1) The common abdominal masses in infants and children were neuroblastoma, Wilms tumor, germ cell tumor, hydronephrosis and hepatoblastoma in decreasing order of frequency. Malignant tumors were 114 cases and benign tumors were 69 cases. 2) The male:female ratio was 110 : 84. In...
Clinical Study of Wilms' Tumor .
Myung Hyun Lee, In Sil Lee, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1984;27(6):603-609.   Published online June 30, 1984
Thirty-five cases of Wilms tumor treated at the Seoul National University Hospital from 1969 to 1983, were analyzed and the results are as follows: 1)Ages at nephrectomy were from 1 monh. to 11 years and 8 months. The mean, age was 3 years and 4 months and the median was 2 years and 9 months. The sex ratio of male...
Clinical Observation of Acute Lymphocytic Leukemia with Mediastinal Mass.
In Sil Lee, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1984;27(4):343-349.   Published online April 30, 1984
Twenty four cases of acute lymphocytic leukemia with mediastinal mass were studied at the Department of Pediatrics, Seoul National University Hospital from September 1965 to August 1983. Analysis were done with regard, to age, sex, chief complaints, organ size (liver, spleen and lymph nodes), initial hemoglobin, white blood cell and platelet count, initial bone marrow findings and lymphoblast surface markers....
Case Report
A Case of Trensient Myeloproliferative Disorder with Down Syndrome.
Dong Gyoon Kim, Jae Ho Lee, Jung Il Noh, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1983;26(10):1024-1028.   Published online October 31, 1983
Transient myeloproliferative disorder has been reported in infants with Down syndrome. Infants with Down syndrome and this transient myeloproliferative disorder often present with signs and symptoms that are clinically and hematologically indistinguishable from congenital acute myelogenous leukemia. In contrast to congenital AML, complete clinical and hematological recovery occurs within weeks to months of diagnosis without any specific anti- leukemic treatment. A case of transient myeloproliferative disorder...
Original Article
A Study on Frequency of Malignant Tumors in Children.
Chang Yee Hong, Hyo Seop Ahn, Byung Kwan Sohn, Son Moon Shin, In Sil Lee
Clin Exp Pediatr. 1983;26(5):489-498.   Published online May 31, 1983
Five hundred and thirty-nine cases of malignant tumors (excluding leukemia) under 15 years of age who were admitted to Seoul National University Hospital from January 1967 to December 1981 were reviewed and analysed. Three hundred and ninety-nine cases of leukemia were seen during the same period and total 938 cases of malignancies including leukemia were observed. 1. The frequency of malignant tumors...
Case Report
A Case Report Kostmann Syndrome.
Han Wook Yoo, Son Moon Shin, Hyo Seop Ahn, Yong Choi, Chang Yee Hong
Clin Exp Pediatr. 1983;26(3):284-288.   Published online March 31, 1983
Kostmann syndrome (Infantile genetic agranulocytosis), a disease characterized by recurrent infections leading to death in infancy, shows an agranulocytosis with variable monocytosis, eosinophilia in the peripheral blood, accompanied by the maturation arrest of the myelocytic series at the promyelocyte-myelocyte level. A 2 years 3 month old female patient with Kostmann syndrome is reported, who has suffered from recurrent infections since 1 month of age. During...
Two Case of Ginaotti-Crosti Syndrome.
Jae Ho Lee, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Kwng Wook Ko, Won Suk Kim
Clin Exp Pediatr. 1982;25(12):1289-1294.   Published online December 31, 1982
The Gianotti-Crosti syndrome is an. infrequently recognized disorder with distinctive clinical features. We have experienced two cases of Gianotti-Crosti syndrome diagnosed by clinical manifestation, laboratory data and histopathologic finding of skin. Case one; An 18-month-old girl was admitted to the pediatric ward with the chief complaint of erythematous rash. Its onset was preceded by an. upper respiratory tract infection. She had a wide spread erythematous...
Original Article
Testicular Leukemia.
Young Jin Hong, Jung Yeun Choi, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1982;25(1):29-35.   Published online January 31, 1982
Leukemic infiltration of the testes has been relatively rare disease. But increased survival due to advance in the treatment of childhood leukemia has been associated with an increase in incidence of leukemic infiltration of the tests. Six of 66 male children with acute lymphocytic leukemia and 2 of 2 male children with leukemic transformation on non-Hodgkin's lymphoma, who have been...
Clinical Observation on Factors Influencing Survival in Pediatric Acute Lymphocytic Leukemia.
Chang Yee Hong, Jung Yeun Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1982;25(1):8-18.   Published online January 31, 1982
Sixty two properly treated acute lymphocytic leukemia cases who were diagnosed at SNUH, from 1958 to July, 1981 were studied. Among them, 20 cases had survived more than 3 years and 42 cases survived less than 3 years. The 11 cases of 20 are now alive and off theray and the remainder 9 cases were expired after survival for more...
Histiocytic Medullary Reticulosis in Children: Report of Four Cases and Analysis of Previously Reported Cases.
Eue Cho Yang, Jae Ho Lee, Soon Ung Kang, Hyo Seop Ahn, Chang Yee Hong, Je G Chi, Yong Il Kim
Clin Exp Pediatr. 1981;24(10):928-941.   Published online October 15, 1981
Histiocytic Medullary Reticulosis(H.M.R.) is a rapidly progressing fatal disease seen most often in adults, but it has been reported in children younger than 15 years of age. H.M.R. is clinically characterized by fever, wasting generalized lymphadenopathy and hepatosplenomegaly. In the terminal stage, jaundice, purpura, anemia and pancytopenia are all present with or without skin involvement. Cardinal pathologic features are systemized...
Treatment of Aplastic Anemia with Lithium Carbonate.
Chang Yee Hong, Hyo Seop Ahn
Clin Exp Pediatr. 1981;24(7):620-624.   Published online July 15, 1981
The effect of lithium carbonate was investigated on the five cases of aplastic anemia with measuring of serum level and EKG check. Reticulocyte count increased slightly only in one case. Hemoglobin, WBC and platelet count did not show any significant increase in all cases. No apparent side effect, including EKG finding, was observed.
Case Report
A Case of Congenital Hepatic Fibrosis.
Son Moon Shin, Sang Il Lee, Joong Gon Kim, Hyo Seop Ahn, Hyung Ro Moon, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1981;24(6):577-583.   Published online June 15, 1981
Congenital hepatic fibrosis is a relatively rare liver disease in children and young adults,that is characterized by stony hard hepatomegaly and portal hypertension with relative preservation of liver function and underlying architecture. Since this Condition was first delineated by Kerr et al in 1961, approximately over 150 cases have been reported in the literature. However, congenital hepatic fibrosis was not...
Original Article
Clinical Obseervation for Hematologic Disorders in Children.
Eung Sang Choi, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Chang Yoo Hong
Clin Exp Pediatr. 1981;24(3):235-244.   Published online March 15, 1981
Nine hundred and twenty-three cases of hematologic disorders in children who were admi-tted to department of pediatrics, SNUH, from 1955 to Oct. 1980 were analysed. The patients consisted of 624 males and 299 females. The results were as follows; 1.Mean annual percentage of hematologic patients among total admitted patients was 6.8%. 2.The peak age incidence of various hematologic disorders was...
Case Report
Fanconi Anemia.
Sang Il Lee, Young Yul Koh, Jung Gi Suh, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1981;24(2):153-163.   Published online February 15, 1981
Five cases of Fanconi anemia were observed during these 7 *years. It acounts for about 6.7% of the total 75 aplastic anemia seen during those same period in SNUH. Three were boys and two were girls. The initial symptom was nasal bleeding or pallor which observed between the age of 2 years and 6 years. They all revealed growth retardation...
Late Hemorrhagic Disease of Infancy.
Joong Gon Kim, Young Min Ahn, Hyo Seop Ahn, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1980;23(7):572-577.   Published online July 15, 1980
A hemorrhagic disease due to prothrombin complex deficiency os described in 4 infants from 1 to 11 months of age. This disease is different from the hemorrhagic disease of the newborn. The main differences are that it is found in an older age group and that intracranial hemorrhages are frequent. Rapid clinical and laboratory response after vitamin K therapy are...
Original Article
Brain Abscess in Congenital Heart Disease
Chang Yee Hong, Hyo Seop Ahn, Heung Jai Lee, Byung Kwan Son
Clin Exp Pediatr. 1976;19(12):904-914.   Published online December 31, 1976
Clinical observation was performed on 9 cases of brain abscess which were complicated with cyanotic congenital heart disease which were seen at the Department of Pediatrics, Seoul National University Hospital, during the past 19 years from 1957 to 1976. 1. During the last 19 years 1, 296 cases of [congenital heart disease were observed, and among these, 432 cases were cyanotic....
Case Report
A Case of Acute Cerebellitis
Yong Soo Yoon, Hyo Seop Ahn, Sang Hyeup Kim
Clin Exp Pediatr. 1975;18(10):751-757.   Published online October 31, 1975
A case of acute cerebellitis in a 6 year and 8 month-old male was presented. The patient was admitted with the chief complaints of gait ataxia, inability to sit and stand alone after awaken from bed since the morning of admission day. Six days prior to admission, fever, anorexia, and malaise developed and soon after followed by pruritic maculo-papular rashes...
Original Article
Clinical Observation of Aplastic Anemia in Children
Chang Yee Hong, Hyo Seop Ahn, Heung Jai Lee
Clin Exp Pediatr. 1975;18(7):489-498.   Published online July 31, 1975
Clinical observation was performed on 64 cases of aplastic anemia which were seen at the Department of Pediatrics, Seoul National University Hospital, during the past 14 years 2 months period from Aug. 1960 to Oct. 1974. The results were as follows; 1.During the last 14 years 2 months, 64 cases of aplastic anemia were observed, which represents about 0.6% of...
Case Report
A Case of Chronic Atrial Tachycardia
Hyo Seop Ahn, Yong Choi, Tae Woon Kim, Chong Ku Yoon, Chang Yee Hong, Johng Kun Ahn
Clin Exp Pediatr. 1974;17(2):149-153.   Published online February 28, 1974
A case of chronic atrial tachycardia in a 1 1 year and 10 month-old boy is reported. The patient was admitted with the chief complaints of palpitation and chest discomfort Tachycardia persisted till discharge but subjective symptoms were disappeared. Digitalis therapy provoked partial AV block and decreased ventricular rate. Auricular rate was also slightly decreased. The review of literature was made briefly.
Original Article
Statistical Observation of Heart Disease in Children
Hyo Seop Ahn
Clin Exp Pediatr. 1973;16(12):935-954.   Published online December 31, 1973
Statistical observation was performed on 1,278 cases of heart disease which were seen at the department of pediatrics, Seoul National University Hospital, during the past 15 years and 9 months period from Oct. 1957 to June 1973. The results were as follows; 1.During the last 15 years and 9 months, 1,278 cases of heart disease were observed, which represents about...
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